| Product Name | Klk8, 29-260aa, Mouse, Baculovirus |
|---|---|
| Description | Klk8, as known as kallikrein-8, is a member of the tissue kallikrein family. This protein is capable of degrading a number of proteins such as casein, fibrinogen, fibronectin and collagen type IV. Also, it cleaves L1CAM in response to increased neural activity and induces neurite outgrowth and fasciculation of cultured hippocampal neurons. It plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Recombinant mouse Klk8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Kallikrein-8, Klk8, BSP1, NP, Nrpn, Prss19, Neuropsin |
| Host | Virus |
| Molecular Weight |
23.8kDa (213aa) 28-40kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | QGSKILEGRE CIPHSQPWQA ALFQGERLIC GGVLVGDRWV LTAAHCKKQK YSVRLGDHSL QSRDQPEQEI QVAQSIQHPC YNNSNPEDHS HDIMLIRLQN SANLGDKVKP VQLANLCPKV GQKCIISGWG TVTSPQENFP NTLNCAEVKI YSQNKCERAY PGKITEGMVC AGSSNGADTC QGDSGGPLVC DGMLQGITSW GSDPCGKPEK PGVYTKICRY TTWIKKTMDN RDLEHHHHHH |
| Tag | His-tag |
| Reactivity | Mouse |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Kishibe M., et al, (2012) J. Invest. Dermatol. 132:1717-1724. Attwood BK., et al, (2011) Nature 473:372-375. |
| Background | Klk8, as known as kallikrein-8, is a member of the tissue kallikrein family. This protein is capable of degrading a number of proteins such as casein, fibrinogen, fibronectin and collagen type IV. Also, it cleaves L1CAM in response to increased neural activity and induces neurite outgrowth and fasciculation of cultured hippocampal neurons. It plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Recombinant mouse Klk8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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