| Product Name | KSL 128114 |
|---|---|
| Description | KSL 128114 is a potent, and metabolically stable peptide inhibitor of syntenin, which binds the PDZ1 domain of syntenin with nanomolar affinity. KSL 128114 is resistant toward degradation in human plasma and mouse hepatic microsomes and shows an inhibitory effect on primary glioblastoma cell viability. KSL 128114 significantly extends survival time in a patient derived glioblastoma xenograft mouse model. |
| Synonyms | Ac-rRrGrKkRr-SHW(Tle)(Chg)DI, KSL 128114, KSL-128114, KSL128114, PP-030 |
| Molecular Weight | 2201.6 Da |
| Target | Protein-protein interactions |
| Amino Acid Sequence | Ac-rRrGrKkRrSHW(Tle)(Chg)DI |
| Form | Freeze dried solid |
| Purity | >95% |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal is acetylated, arginines 1, 3, 5 and 9 and lysine 7 are D amino acids, Tle is tert butyl glycine and Chg is cyclohexylglycine |
| References |
Haugaard-Kedström et al (2021) A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem. 64 1423 PMID: 33502198 Related areasAll peptides >All protein-protein modulators >All cancer research categories> |
| Supplier | Isca Biochemicals Limited |
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