| Product Name | Ksp-Cadherin Monoclonal Antibody |
|---|---|
| Description | Kidney specific calcium binding protein (Ksp-Cadherin) is a new member of cadherin family. This protein has a kidney specificity. In kidney tissue, Ksp-Cadherin is only expressed in renal tubular epithelial basement membrane and collecting duct epithelium, and not expressed in glomerular, renal interstitial cells and vessels. Many different calcium (the E-cadherin N- cadherin, Cadherin Delta etc.) in renal cell tumors have confirmed that the loss of these adhesion molecules may be related with tumor dedifferentiation and lymph node metastasis. Research of Shen et al. have showed that Ksp-Cadherin has a high sensitivity up to 100% (13/13) in chromophobe renal cell carcinoma, and 95% (19/20) in renal oncocytoma.Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Synonyms | Cadherin-16,Kidney-specific cadherin,Ksp-cadherin |
| Host | Mouse |
| Clone | AS1A27 |
| Immunogen | Full length protein from eukaryotic expression system. |
| Isotype | IgG |
| Specificity | This antibody detects endogenous levels of Ksp-Cadherin |
| Reactivity | Human |
| Applications | IHC |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Uniprot | O75309 |
| Background | Kidney specific calcium binding protein (Ksp-Cadherin) is a new member of cadherin family. This protein has a kidney specificity. In kidney tissue, Ksp-Cadherin is only expressed in renal tubular epithelial basement membrane and collecting duct epithelium, and not expressed in glomerular, renal interstitial cells and vessels. Many different calcium (the E-cadherin N- cadherin, Cadherin Delta etc.) in renal cell tumors have confirmed that the loss of these adhesion molecules may be related with tumor dedifferentiation and lymph node metastasis. Research of Shen et al. have showed that Ksp-Cadherin has a high sensitivity up to 100% (13/13) in chromophobe renal cell carcinoma, and 95% (19/20) in renal oncocytoma.Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| Supplier | Elabscience |
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