| Product Name | KYL |
|---|---|
| Description |
KYL is an EphA4 receptor tyrosine kinase inhibitor with a Kd of 0.8 μM. KYL inhibits EphA4-EphrinA5 interactions with an IC50 of 6.34 μM. Through EphA4 inhibition, KYL can prevent dendritic spine reduction, the blocking of LTP induction and neuronal apoptosis caused by amyloid-β oligomers (AβOs). EphA4-/- neurons or sh-EphA4-transfected neurons showed reduced synaptotoxicity by AβOs. EphA4/c-Abl activation is a key-signalling event that mediates the synaptic damage induced by AβOs. |
| Synonyms | EphA4 blocking peptide |
| Molecular Weight | 1465.75 Da |
| Target | Receptor tyrosine kinases |
| Amino Acid Sequence | KYLPYWPVLSSL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 676657-00-4 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID: 22489865Vargas et al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One 9 e92309 PMID: 24658113Tamura et al (2020 EphA4 regulates Aβ production via BACE1 expression in neurons. FASEB J. 34(12):16383 PMID: 33090569 Related areasAll peptides >All receptor tyrosine kinase modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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