| Product Name | LAMTOR2, 1-125aa, Human His tag |
|---|---|
| Description | LAMTOR2 is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Recombinant human LAMTOR2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | Ragulator complex protein LAMTOR2, ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3, RP11-336K24.9 |
| Host | E. coli |
| Molecular Weight | 23.8 kDa(210aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMLRPKAL TQVLSQANTG GVQSTLLLNN EGSLLAYSGY GDTDARVTAA IASNIWAAYD RNGNQAFNED NLKFILMDCM EGRVAITRVA NLLLCMYAKE TVGFGMLKAK AQALVQYLEE PLTQVAAS |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl, 1mM DTT |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Bohn G., et al. (2007) Nat. Med. 13:38-45 Sancak Y., et al. (2010) Cell. 141:290-303 |
| Background | LAMTOR2 is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Recombinant human LAMTOR2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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