| Product Name | LDLR chaperone MESD, 30-224aa, Mouse |
|---|---|
| Description | MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | 2210015O11Rik, AW537813, mesd, mKIAA0081, msd |
| Host | E. coli |
| Molecular Weight |
25.6kDa (232aa) 28-40kDa (SDS-PAGE under reducing conditions) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL |
| Tag | His-tag |
| Reactivity | Mouse |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Lu W., et al. (2010) Biochemistry. 49(22): 4635-43. Hoshi T., et al. (2013) FEBS Lett. 587(23): 3749-54. |
| Background | MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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