| Product Name | LDN 57444 |
|---|---|
| Description | LDN 57444 is an inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity with a Ki of 0.4 μM. UCH-L1 is a deubiquitinating enzyme that is abundantly expressed in the brain, and its activity is required for normal synaptic function. Inhibition by LDN 57444 causes cell death through the apoptosis pathway, increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. |
| Synonyms | 668467-91-2, LDN 57444, PI-001, PI001, UCH-L1, ubiquitin C-terminal hydrolase-L1, ubiquitin proteasome |
| Molecular Weight | 397.64 Da |
| Target | Deubiquitinating enzymes |
| Amino Acid Sequence | 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) |
| Form | Freeze dried solid |
| Purity | >98% by HPLC |
| Cas Number | 668467-91-2 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837 PMID: 14522054 Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109 PMID: 18622688Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857 PMID: 19535597 Related areasAll small molecules >All deubiquitinating enzyme modulators >All neuroscience research areas > |
| Supplier | Isca Biochemicals Limited |
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