| Product Name | Leupeptin hemisulfate |
|---|---|
| Description | Leupeptin is a reversible inhibitor of trypsin-like proteases and cysteine proteases, including trypsin, plasmin, papain, cathepsin B, H and L1-3. Leupeptin also blocks various apoptotic pathways in T cells and can inhibit activation-induced programmed cell death. Leupeptin is widely used in cell lysis buffers to protect proteins from degradation, at a typical working concentration of 1 μM (0.5 μg/mL). |
| Synonyms | trypsin-like proteases, 103476-89-7, Leupeptin, PI-010, PI010, cathepsin B, cysteine proteases, papain, plasmin, trypsin |
| Molecular Weight | 475.04 Da |
| Target | Other proteases |
| Amino Acid Sequence | LLR |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 103476-89-7 |
| Storage | Store dry, dark and frozen |
| Notes | Modifications: Leu-1 = N-terminal Acetyl, Arginine-3 = Arginal |
| References |
Aoyagi et al (1969) Leupeptins, new protease inhibitors from actinomycetes. J. Antibiot. 22 283 PMID: 5810993Barrett et al (1981) Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol. 80 535 PMID: 7043200Sarin et al (1995) A protease-dependent TCR-induced death pathway in mature lymphocytes. J. Immunol. 154(11) 5806 https://www.jimmunol.org/content/154/11/5806PubChem - Leupeptin hemisulphate Related areas All peptides >All other protease modulators >All regulatated cell death research categories > |
| Supplier | Isca Biochemicals Limited |
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