| Product Name | LIMK-1/2 (phospho Thr508/505) Rabbit Polyclonal Antibody |
|---|---|
| Description | LIM domain kinase 1(LIMK1) Homo sapiens There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog |
| Synonyms | LIMK1; LIMK; LIM domain kinase 1; LIMK-1; LIMK2; LIM domain kinase 2; LIMK-2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human LIMK-1/2 (phospho Thr508/505) |
| Isotype | IgG |
| Molecular Weight | 72 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC-P, WB |
| Diluent Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
| Concentration | 1 mg/ml |
| Storage | Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Supplier | ELK Biotechnology |
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