Lin28, 42-209aa, Human

Proteins, Recombinant
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Product Name Lin28, 42-209aa, Human
Applications SDS-PAGE
Background Lin-28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Recombinant Lin28 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 27.4 kDa (244aa), confirmed by MALDI-TOF.
NCBI Accession # NP_078950
Purity > 90% by SDS-PAGE
References Moss E.G., et al. (2003) Dev. Biol. 258:432-442
Heo I., et al. (2009) Cell. 138:696-708.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1, Zinc finger CCHC domain-containing protein 1 AL024421.Lin 28, Lin 28 homolog, Tex17, Lin28a, Lin 28 homolog (C, elegans), Lin 28 homolog A, RNA binding protein lin 28, Zinc finger CCHC domain containing protein 1.
Tag T7 tag

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