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|Product Name||LSM2, 1-95aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMLFYSF FKSLVGKDVV VELKNDLSIC GTLHSVDQYL NIKLTDISVT DPEKYPHMLS VKNCFIRGSV VRYVQLPADE VDTQLLQDAA RKEALQQKQ|
|Background||LSM2 (U6 snRNA-associated Sm-like protein LSm2) belongs to the snRNP Sm proteins family. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. It is involved in pre-mRNA splicing. Recombinant human LSM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1.0 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH7.5) containing 20% glycerol 0.1M Nacl, 1mM DTT|
|Intended Use||For Research Use Only|
|Molecular Weight||42.3 kDa (398aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_067000|
|Purity||> 90% by SDS-PAGE|
|References||Lehner, Ben, et al. (2004) Genome Res. (United States) 14 (7): 1315-23.
Achsel T., et al. (1999) EMBO J. 18:5789-5802
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||U6 snRNA-associated Sm-like protein LSm2, G7b, snRNP|
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