| Product Name | LUM, 19-338aa, Human, Baculovirus |
|---|---|
| Description | LUM, also known as lumican, is a member of the class II small leucine-rich proteoglycan family. It is a major component of the cornea, dermal, and muscle connective tissues. It regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. It may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Recombinant human LUM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Lumican, LUM, LDC, SLRR2D |
| Host | Virus |
| Molecular Weight |
35.7kDa (332aa) 18-57kDa (SDS-PAGE under reducing conditions.) |
| Amino Acid Sequence | ADLQYYDYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLNHHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.25mg/ml (determined by Absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Yamamoto T., et al. (2013) Oncol Rep. 30:1609-1621. Saika S., et al. (2000) J Biol Chem. 275:2607-2612. |
| Background | LUM, also known as lumican, is a member of the class II small leucine-rich proteoglycan family. It is a major component of the cornea, dermal, and muscle connective tissues. It regulates collagenous matrix assembly as a keratan sulfate proteoglycan in the cornea and is also present in the connective tissues of other organs and embryonic corneal stroma as a glycoprotein. It may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Recombinant human LUM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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