| Product Name | Magainin 1 |
|---|---|
| Description | Magainin 1 is a 23 amino acid amphipathic cationic peptide with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainin 1 (and Magainin 2) are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2 (HSV 1 and 2) |
| Synonyms | 108433-99-4, AM-100, AM100, African clawed frog Xenopus laevis, GIGKFLHSAGKFGKAFVGEIMKS, H-GIGKFLHSAGKFGKAFVGEIMKS-OH, Magainin 1, amphipathic cationic peptide, antimicrobial, cancer, cytotoxic, haemolytic, hemolytic, inhibit growth of bacteria by permeabilizing the cell membranes, lipid matrix, membranes |
| Molecular Weight | 2409.8 Da |
| Target | Antibacterials,Antivirals |
| Amino Acid Sequence | GIGKFLHSAGKFGKAFVGEIMKS |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 108433-99-4 |
| Storage | Store frozen and desiccated in the dark |
| Notes | Modifications: None |
| References |
Zasloff (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. 84(15) 5449 PMID: 3299384 Nascimento et al (2012) Evaluation of Magainin I interactions with lipid membranes: An optical and electrochemical study. Chem. Phys. Lipids 165(5) 537 PMID: 22634545Watanabe and Kawano (2016) Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. Anal. Sci. 32(1) 57 PMID: 26753706PubChem - Magainin 1 Related areas All antimicrobial peptides >All antiviral agents >All immunology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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