| Product Name | MAGED1, 504-760aa, Human |
|---|---|
| Description | MAGED1, as known as Melanoma-associated antigen D1, is expressed in almost all normal adult tissues. It has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. It has been involved in Prader-Willi syndrome, which includes hyperphagia, repetitive and compulsive behaviors, and cognitive impairment. Recombinant human MAGED1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | DLXIN-1, NRAGE |
| Host | E. coli |
| Molecular Weight | 46.9kDa (426aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSLRPSPNS RASQNPGAAQ PRDVALLQER ANKLVKYLML KDYTKVPIKR SEMLRDIIRE YTDVYPEIIE RACFVLEKKF GIQLKEIDKE EHLYILISTP ESLAGILGTT KDTPKLGLLL VILGVIFMNG NRASEAVLWE ALRKMGLRPG VRHPLLGDLR KLLTYEFVKQ KYLDYRRVPN SNPPEYEFLW GLRSYHETSK MKVLRFIAEV QKRDPRDWTA QFMEAADEAL DALDAAAAEA EARAEARTRM GIGDEAVSGP |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Concentration | 0.5 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Dombret C. et al. (2012) Hum Mol Genet. 21:4703-4717 Mouri ,. et al. (2012) J Neurosci. 32:4562-4580. |
| Background | MAGED1, as known as Melanoma-associated antigen D1, is expressed in almost all normal adult tissues. It has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. It has been involved in Prader-Willi syndrome, which includes hyperphagia, repetitive and compulsive behaviors, and cognitive impairment. Recombinant human MAGED1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Supplier | ARP |
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