| Product Name | Map2k4 Antibody, HRP conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against Dual specificity mitogen-activated protein kinase kinase 4 conjugated to HRP |
| Synonyms | Map2k4 antibody; Jnkk1 antibody; Mek4 antibody; Mkk4 antibody; Prkmk4 antibody; Sek1 antibody; Serk1 antibody; Skk1 antibody; Dual specificity mitogen-activated protein kinase kinase 4 antibody; MAP kinase kinase 4 antibody; MAPKK 4 antibody; EC 2.7.12.2 antibody; C-JUN N-terminal kinase kinase 1 antibody; JNK kinase 1 antibody; JNKK 1 antibody; JNK-activating kinase 1 antibody; MAPK/ERK kinase 4 antibody; MEK 4 antibody; SAPK/ERK kinase 1 antibody; SEK1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP |
| Immunogen | Recombinant mouse Dual specificity mitogen-activated protein kinase kinase 4 protein (2-397AA) |
| Isotype | IgG |
| Target | Map2k4 |
| Reactivity | Mouse |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | P47809 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. |
| Supplier | Cusabio |
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