| Product Name | MAP2K6, 53-314aa, Human (Denatured) |
|---|---|
| Description | MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | Mitogen-activated protein kinase kinase 6, Mitogen-activated protein kinase kinase 6, MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3 |
| Host | E. coli |
| Molecular Weight | 50.4 kDa (471aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MLEPIMELGR GAYGVVEKMR HVPSGQIMAV KRIRATVNSQ EQKRLLMDLD ISMRTVDCPF TVTFYGALFR EGDVWICMEL MDTSLDKFYK QVIDKGQTIP EDILGKIAVS IVKALEHLHS KLSVIHRDVK PSNVLINALG QVKMCDFGIS GYLVDEVAKE IDAGCKPYMA PERINPELNQ KGYSVKSDIW SLGITMIELA ILRFPYDSWG TPFQQLKQVV EEPSPQLPAD KFSAEFVDFT SQCLKKNSKE RPTYPELMQH PFF |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in Phosphate buffer saline (pH 7.4) containing 20% glycerol, 1mM DTT |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles |
| References | Manning G., et al. (2002) Science 298 (5600): 1912-34 Pearson G., et al. (2002) Endocr. Rev. 22 (2): 153-83 |
| Background | MAP2K6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MAP2K6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Recombinant human MAP2K6, fused to His-tag at N-terminus, was expressed in E.coli. |
| Supplier | ARP |
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