| Product Name | MAPK8IP1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to MAPK8IP1 |
| Synonyms | MAPK8IP1 antibody; IB1 antibody; JIP1 antibody; PRKM8IP antibody; C-Jun-amino-terminal kinase-interacting protein 1 antibody; JIP-1 antibody; JNK-interacting protein 1 antibody; Islet-brain 1 antibody; IB-1 antibody; JNK MAP kinase scaffold protein 1 antibody; Mitogen-activated protein kinase 8-interacting protein 1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide of human MAPK8IP1 |
| Isotype | IgG |
| Target | MAPK8IP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Form | Liquid |
| Diluent Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Uniprot | Q9UQF2 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. |
| Supplier | Cusabio |
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