| Product Name | MDL 28170 |
|---|---|
| Description | MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo. |
| Synonyms | Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, |
| Molecular Weight | 382.45 Da |
| Target | Calcium sensitive proteases |
| Amino Acid Sequence | Carbobenzoxy-VA-CHO |
| Form | Freeze dried solid |
| Purity | >95% (HPLC) |
| Cas Number | 88191-84-8 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: N terminal is carbobenzoxy, phenylalanine is terminal aldehyde |
| References |
Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17 PMID: 9637399Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150 PMID: 1877091Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960 PMID: 17600513 Related areasAll peptides >All calcium sensitive protease modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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