| Product Name | Melittin (synthetic) |
|---|---|
| Description | Melittin is a cationic, haemolytic component of honey bee venom used to study cell and liposome lysis. Melittin is a positively charged, amphipathic 26-amino-acid peptide that associates with the phospholipids of membrane bilayers, causing cell death by forming transmembrane toroidal pores at nanomolar concentrations. Melittin also inhibits Gs and stimulates Gi activity, inhibits protein kinase C and cAMP-dependent protein kinases and is a Na+/K+ ATPase inhibitor. Melittin has antitumoural effects in multiple cancer types, and can induce potent and highly selective cell death in triple negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER2) enriched breast carcinoma, with negligible effects on normal cells. We also offer melittin with a C-terminal cysteine at the C-terminal. This allows melittin to be labelled with any maleimide linked tag, allowing fluorescent labelling or biotinylation. Please contact us for any further details of these services. |
| Synonyms | 20449-79-0, AM-050, AM050, GIGAVLKVLTTGLPALISWIKRKRQQ-NH2, H-GIGAVLKVLTTGLPALISWIKRKRQQ-NH2, Melittin, honey bee venom, mellitin |
| Molecular Weight | 2846.5 Da |
| Target | Kinases,Antibacterials |
| Amino Acid Sequence | GIGAVLKVLTTGLPALISWIKRKRQQ |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 20449-79-0 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811 PMID: 9663445Shi et al (2016) Antimicrobial peptide melittin against Xanthomonas oryzae pv. oryzae, the bacterial leaf blight pathogen in rice. Appl. Microbiol. Biotechnol. 100 5059 PMID: 26948237 Duffy et al (2020) Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer. Precis. Onc. 4 24 https://doi.org/10.1038/s41698-020-00129-0 Related areasAll antimicrobial peptides >All kinase modulators >All immunology research categories >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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