| Product Name | MFAP4, 22-255aa, Human |
|---|---|
| Description | MFAP4, also as known as microfibrillar-associated protein 4, belongs to Fibrinogen protein family and contains 1 fibrinogen C-terminal domain. This protein has similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. Deletion of MFAP4 was found in 30 of 31 patients with Smith-Magenis syndrome (SMS), a clinically recognizable multiple congenital anomaly/mental retardation syndrome. Recombinant human MFAP4 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | microfibrillar-associated protein 4, Microfibril associated glycoprotein 4, Microfibril-associated glycoprotein 4 |
| Host | E. coli |
| Molecular Weight | 24.1 kDa (219aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMVSGIR GDALERFCLQ QPLDCDDIYA QGYQSDGVYL IYPSGPSVPV PVFCDMTTEG GKWTVFQKRF NGSVSFFRGW NDYKLGFGRA DGEYWLGLQN MHLLTLKQKY ELRVDLEDFE NNTAYAKYAD FSISPNAVSA EEDGYTLFVA GFEDGGAGDS LSYHSGQKFS TFDRDQDLFV QNCAALSSGA FWFRSCHFAN LNGFYLGGSH LSYANGINWA QWKGFYYSLK RTEMKIRRA |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Lausen M, et al. (1999) J Biol Chem. 274(45):32234-40. Zhao, Z., et al. (1995) Mol. Genet. 4: 589-597. |
| Background | MFAP4, also as known as microfibrillar-associated protein 4, belongs to Fibrinogen protein family and contains 1 fibrinogen C-terminal domain. This protein has similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. Deletion of MFAP4 was found in 30 of 31 patients with Smith-Magenis syndrome (SMS), a clinically recognizable multiple congenital anomaly/mental retardation syndrome. Recombinant human MFAP4 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Supplier | ARP |
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