| Product Name | MG 132 |
|---|---|
| Description | MG 132 is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome with an IC50 of 100 nM with Z-LLL-AMC as the substrate. MG 132 also inhibits calpain, suppresses gastric cancer cell proliferation and induces macro-autophagy. It also inhibits TNF-α-induced NF-κB activation and IκBα degradation and induces neurite outgrowth in PC12 cells. MG 132 inhibits SARS-CoV-2 Mpro in vitro and can inhibit viral replication. |
| Synonyms | Z-LLL-al, Z-Leu-Leu-Leu-CHO |
| Molecular Weight | 475.63 Da |
| Target | Proteasome |
| Amino Acid Sequence | Z-LLL-CHO |
| Form | Freeze dried solid |
| Purity | >98% by HPLC |
| Cas Number | 133407-82-6 |
| Storage | Store desiccated, frozen and in the dark |
| Notes | Modifications: N-terminal N-[(Phenylmethoxy)carbonyl, Leucine 3 is leucinal |
| References |
Banerjee and Liefshitz (2001) Potential of the proteasome inhibitor MG-132 as an anticancer agent, alone and in combination. Anticancer Res. 21 3941 PMID: 11911275Tsubuki et al (1996) Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-Leucine and tri-Leucine. J.Biochem. 119 572 PMID: 8830056Ma et al (2020) Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Res. 30 678 PMID: 32541865 Related areas All peptides >All proteasome modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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