| Product Name | MLCK inhibitor peptide 18 |
|---|---|
| Description |
MLCK inhibitor peptide 18 is a selective cell permeable inhibitor of myosin light chain kinase with an IC50 of 50 nM. MLCK inhibitor peptide 18 displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. In vitro and in vivo treatment with the MLCK inhibitor peptide 18 attenuates the increased epithelial monolayer permeability and occludin endocytosis caused by intestinal anoxia/reoxygenation (A/R) injury. |
| Synonyms | Myosin Light Chain Kinase Inhibitor Peptide 18, Peptide 18 |
| Molecular Weight | 1324.64 Da |
| Target | Kinases |
| Amino Acid Sequence | RKKYKYRRK-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 224579-74-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 42 910 PMID: 10072688Jin and Blikslager (2016) Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury. American J. Physiology-Cell Physiology 311(6) C996 PMID: 27760753Huang et al (2020) Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway. Phytomedicine 68 153179 PMID: 32062328Guide to Pharmacology: MLCK inhibitor peptide 18 Related areasAll peptides >All kinase modulators > |
| Supplier | Isca Biochemicals Limited |
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