| Product Name | MOB1A Antibody, HRP conjugated |
|---|---|
| Description | Rabbit polyclonal antibody against MOB1A conjugated to HRP |
| Synonyms | B1; Mps One Binder kinase activator like 1B (yeast) antibody; C2orf6 antibody; Chromosome 2 open reading frame 6 antibody; FLJ10788 antibody; FLJ11595 antibody; MATS1 antibody; MOB kinase activator 1A antibody; MOB1 antibody; Mob1 alpha antibody; Mob1 homolog 1B antibody; MOB1 Mps One Binder homolog A antibody; MOB1 Mps One Binder kinase activator like 1B antibody; Mob1A antibody; MOB4B antibody; Mob4B protein antibody; MOBK1B antibody; Mobkl1b antibody; MOL1B_HUMAN antibody; Mps one binder kinase activator like 1B antibody; Mps one binder kinase activator-like 1B antibody; Protein Mob4B antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | HRP |
| Immunogen | Recombinant human MOB kinase activator 1A protein (2-216AA) |
| Isotype | IgG |
| Target | MOB1A |
| Reactivity | Human |
| Applications | ELISA |
| Form | Liquid |
| Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Uniprot | Q9H8S9 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. |
| Supplier | Cusabio |
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