| Product Name | MOG (35-55) (human) |
|---|---|
| Description | MOG (35-55) (human) is a truncated fragment of human myelin oligodendrocyte glycoprotein (MOG), the transmembrane glycoprotein expressed at the surface of oligodendrocyte cells and on the outermost surface of the myelin sheath, which can be used for the induction of experimental autoimmune encephalomyelitis in mouse and rat models. In contrast to MOG (35-55) (rat), Mog (35-55) (human) is only weakly encephalitogenic but both induce antibodies that are equivalent in titer and IgG subclass, demonstrating that EAE can be induced in C57BL/6 mice by two different mechanisms |
| Synonyms | 163158-19-8, EAE, H-MEVGWYRPPFSRVVHLYRNGK-OH, MEVGWYRPPFSRVVHLYRNGK, MOG, MOG (35-55) (human), NR-010, NR010, encephalitogenic, experimental autoimmune encephalomyelitis, human myelin oligodendrocyte glycoprotein, myelin sheath |
| Molecular Weight | 2592 Da |
| Target | Epitopes |
| Amino Acid Sequence | MEVGWYRPPFSRVVHLYRNGK |
| Form | Freeze dried solid |
| Purity | >95% by HPLC |
| Cas Number | 163158-19-8 |
| Storage | Store dark, frozen and desiccated |
| Notes | Modifications: None |
| References |
Oliver et al (2003) Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. J. Immunol. 171 (1) 462 PMID: 12817031Haas et al (2005) Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur. J. Immunol. 35(11) 3343 PMID: 16206232 Related areasAll myelin peptides >All immunology categories > |
| Supplier | Isca Biochemicals Limited |
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