| Product Name | Mouse anti-ACTH, clone 57 (Monoclonal) |
|---|---|
| Description | Mouse anti-ACTH, clone 57 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 57 (BGN/1388/66) |
| Immunogen | Synthetic peptide corresponding to the amino acids 1 - 24 (SYSMEHFRWGKPVGKKRRPVKVYP) of the human ACTH conjugated to Keyhole Limpet Haemocyanin. |
| Isotype | IgG1 |
| Reactivity | Human, Rat |
| Applications | ELISA, IF, IHC-P |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.09% sodium azide |
| Concentration | 1.0mg/ml |
| Storage | 2-8°C |
| Notes |
Mouse anti Human ACTH antibody (Clone 57, BGN/1388/66) recognizes 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output. Mouse anti Human ACTH antibody does not recognize 17-39 ACTH (CLIP). It does cross-reacts with rat N-terminal ACTH. |
| References | Hatakeyama, H. et al. (2000) Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells. Possible role in control of blood pressure. Hypertens. 36: 862-865 |
| Supplier | MONOSAN |
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