Mouse anti-Actin Alpha-muscle, clone HHF35, Purified (Monoclonal)
| Product Name | Mouse anti-Actin Alpha-muscle, clone HHF35, Purified (Monoclonal) |
|---|---|
| Description | Mouse anti-Actin Alpha-muscle, clone HHF35, Purified (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HHF35 |
| Immunogen | SDS-extracted protein fraction from Human myocardium |
| Isotype | IgG1 |
| Reactivity | Gallus, Monkey, Human, Porcine, Rabbit, Rat, Zebrafish |
| Applications | IHC-Fr, ELISA, EM, ICC, IHC-P, WB |
| Working Dilutions | ,,,,, |
| Diluent Buffer | PBS with 0.09% sodium azide |
| Concentration | 1 mg/ml |
| Storage | 2-8°C |
| Notes | Among the six actin isoforms described in mammals, two are found in virtually all cells (β- and γ-cytoplasmic), two are detected in smooth muscle cells (α- and γ-smooth muscle) and two are present in striated muscles, one predominantly in skeletal (α-skeletal) and one in cardiac (α-cardiac) muscle cells. These actin isoforms differ slightly in their N-terminus, but the sequence of each of these actins is highly conserved in higher vertebRates. Alpha- muscle actin is present in striated as well as smooth muscle cells, and in pathological tissues derived therefrom.HHF35 reacts with both α-muscle and γ-smooth muscle actin, and therefore reacts with skeletal muscle, cardiac muscle, vascular and visceral smooth muscle cells, pericytes and myoepithelial cells. It is also reactive in myofibroblasts. It does not react with epithelial, endothelial, neural or normal connective tissue cells when applied under the proper conditions to these tissue sections. |
| References | Tsukada et al. Am J of Path 1987;126:51-60. Tsukada et al. Am J of Path 1987;127:389-402. Schmidt et al. Am J of Pathol 1988;131:19-28. Babaev et al. Am J of Path 1990; 136:1031-1042. Nasimento et al. Transpl Proc 2009; 41:4211-4213 |
| Supplier | MONOSAN |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
