| Product Name | Mouse anti-Akt (Phosphorylated), clone LP18 (monoclonal) |
|---|---|
| Description | Mouse anti-Akt (Phosphorylated), clone LP18 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | LP18 |
| Immunogen | A chemically synthesized phosphorylated peptide corresponding to residues around Ser473 of the human Akt molecule. |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tissue culture supernatant with 15mM sodium azide |
| Concentration | Greater than or equal to 300 mg/L |
| Storage | 2-8°C |
| Notes | Akt-1, also referred to as protein kinase B (PKB) or Rac alpha is a member of the Akt serin/threonine protein kinase family. It plays an important role in many biological responses including metabolism, cell survival and growth by phosphorylation and inactivating several targets including GSK 3 beta, caspase 9, BAD and the forkhead transcription factor. Akt-Phos is not recommended for use with PBS, since the use of PBS-based wash buffers and possibly PBS-based antibody diluents gives increased background staining and decreased staining intensity. |
| References | Brazil D et al. Trends in Biochemical Sciences. 2004; 29(5):233–242. Nicholson K et al. Cellular Signalling. 2002; 14:381–395. Lawlor M et al. Journal of Cell Science. 2001; 114:2903–2910 |
| Supplier | MONOSAN |
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