| Product Name | Mouse anti-Alpha-Synuclein, clone KM51 (monoclonal) |
|---|---|
| Description | Mouse anti-Alpha-Synuclein, clone KM51 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | KM51 |
| Immunogen | Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:20-1:40) |
| Diluent Buffer | Tissue culture supernatant with 15mM sodium azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes.Clone KM51 is specific for alpha-synuclein and is unreactive with beta-synuclein. Pretreatment of tissue sections with 98-100% formic acid is also recommended. |
| References | Baba M et al. American Journal of Pathology. 152 (4): 879–884 (1998). Polymeropoulos MH et al. Science. 276: 2045–2047 (1997). Spillantini MG et al. Nature. 388: 839–840 (1997). Weinreb PH et al. Biochemistry. 35 (43): 13709–13715 (1996) |
| Supplier | MONOSAN |
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