Mouse anti-Alpha-Methylacyl-CoA Racemase (AMACR, p504s), Clone EPUM1 (monoclonal)
| Product Name | Mouse anti-Alpha-Methylacyl-CoA Racemase (AMACR, p504s), Clone EPUM1 (monoclonal) |
|---|---|
| Description | Mouse anti-Alpha-Methylacyl-CoA Racemase (AMACR, p504s), Clone EPUM1 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EPMU1 |
| Immunogen | Prokaryotic recombinant protein corresponding to 382 amino acids of the human alpha-methylacyl-CoA racemase molecule. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tissue culture supernatant with 15mM sodium azide |
| Concentration | Greater than or equal to 84 mg/L |
| Storage | 2-8°C |
| Notes | Alpha-methylacyl-CoA racemase (AMACR), also known as p504s, is a mitochondrial and peroxisomal enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism, and is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). Expression is granular and cytoplasmic. AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma. |
| References | Lloyd M et al.FEBS Journal. 2008: 275;1089–1102. Rubin M et al. J. of the Am. Med.Assoc. 2002: 287(13);1662–1670 |
| Supplier | MONOSAN |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
