| Product Name | Mouse anti-Annexin A1, clone MRQ-3 |
|---|---|
| Description | Mouse anti-Annexin A1, clone MRQ-3 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MRQ-3 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 is a useful marker for identifying hairy cell leukemia cells. ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia, it is therefore a useful marker for identifying hairy cell leukemia cells. By contrast, B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villous lymphocytes and patients with variant hairy cell leukemia-as defined by current morphologic, phenotypic, and clinical criteria-are ANXA1-negative. Additionally, aberrant expression of Annexin A1 has been reported in certain types of breast and gastric carcinomas. |
| References | Falini B, et al. Lancet.; 363:1869-70 (2004). Sobral-Leite M, et al. BMC Med.; 13:156 (2015). Cheng TY, et al. Cancer.; 118:5757-67 (2012). Sato Y, et al. Exp Ther Med.; 2:239-43 (2011). Wang KL, et al.. Clin Cancer Res.; 12:4598-604 (2006) |
| Supplier | MONOSAN |
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