| Product Name | Mouse anti-Beta-Catenin, clone 17C2 (monoclonal) |
|---|---|
| Description | Mouse anti-Beta-Catenin, clone 17C2 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 17C2 |
| Immunogen | Prokaryotic recombinant protein corresponding to a 160 amino acid region of the C-terminus of the beta-catenin molecule. |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:150) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 51 mg/L |
| Storage | 2-8°C |
| Notes | The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer. |
| References | Curia MC et al. Modern Pathology. 2008; 21:7-14. Ortega P et al. Clinical Cancer Research. 2008; 14(14):995-1001. Daa T et al. J. of Exp.Clin.Cancer Research. 2005; 24(1):83-87. Fadare O et al. World Journal of Surgical Oncology. 2005; 3(38). Gamachi A et al.Modern Pathology. 2003; 16(11):1124-1131 |
| Supplier | MONOSAN |
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