Mouse anti-Breast Cancer Resistance Protein (ABCG2), clone BXP-34 (Monoclonal)
| Product Name | Mouse anti-Breast Cancer Resistance Protein (ABCG2), clone BXP-34 (Monoclonal) |
|---|---|
| Description | Mouse anti-Breast Cancer Resistance Protein (ABCG2), clone BXP-34 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BXP-34 |
| Immunogen | Mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-Fr, FC |
| Working Dilutions | IHC-fr (1:10-1:20), |
| Diluent Buffer | PBS with 1% BSA and 0.1% sodium azide |
| Concentration | 250 ug/ ml |
| Storage | 2-8°C |
| Notes | BXP-34 Mab was selected after immunization with the mitoxanthrone resistant, BCRP overexpressing cell line MCF7 MR. BXP-34 reacts with an internal epitope of BCRP, a 70 kD transmembrane half-transporter which is involved in multidrug resistance. BXP-34 did not cross-react with the human MDR1, MRP1, MRP2, MRP5 gene products. |
| References | Doyle LA et al. Proc Nat Acad Sci 1998; 95: 15665-15670. Scheffer GL et al. Cancer Res 2000; 60: 2589-2593. van der Kolk DM et al. Blood; 99: 3763-3770. van der Pol MA et al. Haematologica 2003; 88: 134-147 |
| Supplier | MONOSAN |
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