| Product Name | Mouse anti-CD105, clone MEM-226, FITC (Monoclonal) |
|---|---|
| Description | Mouse anti-CD105, clone MEM-226, FITC (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | MEM-226 |
| Conjugate | FITC |
| Immunogen | Recombinant Vaccinia virus containing the human CD105 cDNA. |
| Isotype | IgG2a |
| Reactivity | Human, Rat |
| Applications | FC |
| Diluent Buffer | Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. |
| References | Piao M, Tokunaga O: Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study. J Atheroscler Thromb. 2006 Apr;13(2):82-9 |
| Supplier | MONOSAN |
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