| Product Name | Mouse anti-CD11a, clone 87-6F9 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD11a, clone 87-6F9 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 87-6F9 |
| Immunogen | stimulated human leucocytes |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | IHC-Fr, FA, FC, IF, WB |
| Working Dilutions | ,,,, |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | 87-6F9 Reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells tend to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory response through binding to ICAM 1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 adhesion. 87-6F9 Potently blocks LFA-1 dependent homotypic cell aggregation and was typed in the IVth International Leucocyte Typing Workshop |
| References | Knapp et al. (Eds.), Leukocyte Typing IV, 1989 : sections N1 (pp. 543.551). Petruzzelli L et al. J Immunol 155(2): 854-866 (1995). Edwards CP et al. J Biol Chem 273(44): 28937-44 (1998). Shang XZ et al,. Eur J Immunol 28(6): 1970-1979 (1998). Tian L et al. J Immunol 158(2): 928-936 (1997) |
| Supplier | MONOSAN |
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