| Product Name | Mouse anti-CD11a, clone CRIS-3 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD11a, clone CRIS-3 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CRIS-3 |
| Immunogen | stimulated human leucocytes |
| Isotype | IgG2b |
| Reactivity | Human |
| Applications | IHC-Fr, FC, IF |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | Cris-3 reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells ten to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 heterodimer also called LFA-1. LFA-1 is chiefly responsible for lymphocyte adhesion. |
| References | Reinherz et. al., EL. Leukocyte Typing II. New York: Springer-Verlag (1985). Jain et al. Folia Neuropathol 47(1), 33-42 (2009) |
| Supplier | MONOSAN |
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