| Product Name | Mouse anti-CD11b/CR3, clone BEAR-1 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD11b/CR3, clone BEAR-1 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BEAR-1 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-Fr, FC, IP |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration | 100 ug/ ml |
| Storage | 2-8°C |
| Notes | CD11b is an alpha chain integrin that is expressed as heterodimer noncovalently associated with CD18. CD11b is also designated as CR3, Mac-1, Mo-1 in integrin alphaM subunit and has a molecular weight of 165-170 kDa. The protein mediates PMN and monocytes adherence to endothelium and subsequently PMN extravasation to sites of inflammation. CD11b/CD18 interacts with both matrix and cell surface proteins including the complement component iC3b, extracellular matrix proteins and the third extracellular domain of CD54. CD11b is expressed on human NK-cells, monocytes, granulocytes, T-cells, B-cells and dendritic cells. After activation the expression is upregulated. Bear-1 reacts with the CD11b alpha chain of the CD11b/CD18 (p165, 95) integrin heterodimer complex. |
| References | Keizer; G et al. Eur J Immunol 1985; 15: 1142. Watanabe, A et al Int Arch Allergy Immunl 1992, 98: 308 |
| Supplier | MONOSAN |
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