| Product Name | Mouse anti-CD13, clone 38C12 (monoclonal) |
|---|---|
| Description | Mouse anti-CD13, clone 38C12 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 38C12 |
| Immunogen | Recombinant prokaryotic fusion protein corresponding to the C-terminal region of the extracellular domain. |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:80) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 19 mg/L |
| Storage | 2-8°C |
| Notes | CD13 antigen, also known as aminopeptidase N, is a member of type II integral membrane metalloproteases, which also includes the leukocyte antigens CD10, CD26, CD73 and BP-1. CD13 antigen is a receptor for the coronaviruses which cause respiratory disease in humans and several animal species. The antigen functions as a zinc-binding metalloprotease which plays a role in cell surface antigen presentation by trimming the N-terminal amino acids from MHC class II-bound peptides. CD13 antigen is reported to be expressed on granulocytes, monocytes and their precursors, most acute myeloid leukemias and a smaller proportion of acute lymphoid leukemias. Non-hematopoietic cells which express CD13 antigen include epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi. |
| References | Terauchi M et al.BMC Cancer 2007; 7:140. Agis H et al. Journal of Clinical Pathology 2006; 59 (4):396-402. Röcken C et al. Journal of Clinical Pathology 2005; 58 (10):1069-1075 |
| Supplier | MONOSAN |
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