| Product Name | Mouse anti-CD158b, clone GL183 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD158b, clone GL183 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | GL183 |
| Immunogen | NK cell clone E57 |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | FC, IP |
| Working Dilutions | , |
| Diluent Buffer | PBS |
| Concentration | 1.0 mg/ml |
| Storage | 2-8°C |
| Notes | Mouse anti Human CD158b antibody, clone GL183 recognizes human Killer cell immunoglobulin-like receptor 2DL3, also known as CD158b, KIR-023GB, MHC class I NK cell receptor, p58 natural killer cell receptor clone CL-6 or Natural killer-associated transcript 2. CD158b is a 341 amino acid, ~58 kDa single pass type-1 transmembrane glycoprotein containing two Ig-like C2-type domains. expressed by a subset of NK cells.This antibody also recognizes a ~50 kDa molecule in some NK clones, which is highly homologous to p58.2 in the extracellular domain, but has a shorter cytoplasmic tail (Moretta et al. 1985). Both molecules are members of the newly described natural killer cell receptor family.CD158b functions as a receptor specific for HLA Class I molecules, including Cw3 and related HLA-C alleles. Mouse anti Human CD158b antibody, clone GL183 can restore the lysis by human NK clones of otherwise lysis protected targets expressing Cw3. |
| Supplier | MONOSAN |
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