| Product Name | Mouse anti-CD21, clone 2G9 |
|---|---|
| Description | Mouse anti-CD21, clone 2G9 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 2G9 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells. The antigen is absent on T-lymphocytes, monocytes, and granulocytes. MON 3027 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas. Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma. |
| References | Dillon KM et al. J Clin Pathol.; 55(10):791-4 (2002). Cheuk W, et al. Am J Surg Pathol.; 25:721-31 (2001). Pileri SA, et al.Histopathology.; 41:1-29 (2002). Maeda K, et al. J Histochem Cytochem.; 50:1475-1486 (2002). Biddle DA, et al. Mod Pathol.; 15:50-8 (2002) |
| Supplier | MONOSAN |
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