| Product Name | Mouse anti-CD23, clone 1B12 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD23, clone 1B12 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1B12 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:10-1:50) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are anti-CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.1,3 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. Anti-CD23 is expressed in activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia. |
| References | Kaiserlian, D, et al., Immunology 1993;80:90-95. Aubry, JP et al., Oxford Univ Press- Oxford, NY, Tokyo 1987:417-419. Pallesen G, Oxford Univ Press-Oxford, NY, Tokyo 1987:383-386. Pezzella F et al. Br j Haematol. 2000 Feb;108(2): 369-76. Kurtin PJ et al. Am J Clin Pathol. 1999 Sep;112(3): 319-29 |
| Supplier | MONOSAN |
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