| Product Name | Mouse anti-CD31, clone JC70 |
|---|---|
| Description | Mouse anti-CD31, clone JC70 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | JC70 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | CD31 has cytoplasmic, membranous expression in non-neoplastic and neoplastic vascular endothelial cells.1 It has been used as a tool to identify the vascular origin of neoplasms such as angiosarcomas, Kaposi sarcomas and epithelioid hemangioendothelioma. Immunohistochemical study with CD31 has also been shown useful to detect areas of tumor lymphovascular invasion. Additionally, detection of weak diffuse cytoplasmic CD31 immunoreactivity has been seen in cases of various carcinomas with occasional membranous staining in ductal carcinomas of the breast as well as in intratumoral macrophages. |
| References | Parums DV, et al.. J Clin Pathol. 1990; 43:752-7. Attanoos RL, et al. Thorax. 2000; 55:860-3. Alexander-Sefre F, et al. J Clin Pathol. 2003; 56:786-8. - Ortiz-Hidaldo C, et al. Appl Immunohistochem Mol Morphol. 2000; 8: 334-5. McKenney JK, et al. Am J of Surg Pathol. 2001; 25:1167-73 |
| Supplier | MONOSAN |
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