| Product Name | Mouse anti-CD4, clone 4B12 (monoclonal) |
|---|---|
| Description | Mouse anti-CD4, clone 4B12 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4B12 |
| Immunogen | Prokaryotic recombinant protein corresponding to the external domain of the CD4 molecule. |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with sodium azide |
| Concentration | Greater than or equal to 405 mg/L |
| Storage | 2-8°C |
| Notes | The CD4 molecule (T4) is a single chain transmembrane glycoprotein with a molecular weight of 59 kD. The CD4 antigen is expressed on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes and at a lower level on monocytes and germinal center macrophages. Most cases of cutaneous T cell lymphoma, including mycosis fungoides, express the CD4 antigen and HTLV-1 associated adult T cell leukemia/lymphoma is also generally CD4 positive. |
| References | Arnould L et al. British Journal of Cancer 2006; 94:259-267. Choi HJ et al. British Journal of Dermatology 2006; 154:419-425. Lapperre TS et al. Thorax 2006; 61:115-121. Willemse BWM et al. Respiratory Research 2005; 6:38. Suzuki A et al. Journal of Pathology 2002; 196:37-43 |
| Supplier | MONOSAN |
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