| Product Name | Mouse anti-CD8, clone C8/144B (Monoclonal) |
|---|---|
| Description | Mouse anti-CD8, clone C8/144B (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | C8/144B |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:25-1:100) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | The CD8 (cluster of differentiation 8) antigen is a cell surface glycoprotein made up of two subunits alpha and beta.1 Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes. CD8 is also detected on NK cells, some thymocytes, some null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic Tcells.3 CD8 expression has been found to be negative in Mycosis Fungoides. Rarely does anti-CD8 label non-hematolymphoid neoplasms. |
| References | Rossi, ML, Sanchez, FC, et al., J Clin Path 1988;41:314-319. Stein, H, Lennart, K, et al., Adv Cancer Res 1984;42:67-147. Phan-Dinh-Tuy, F, Niaudet, P, et al., Mol Immun 1982;19:1649-1654. Mason DY et al. J Clin Pathol. 1992:45:1084-8. Nuchols JD et al. J Cutan Pathol 1999;26:169-75 |
| Supplier | MONOSAN |
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