| Product Name | Mouse anti-CD95/FAS antigen, clone B-R18 (Monoclonal) |
|---|---|
| Description | Mouse anti-CD95/FAS antigen, clone B-R18 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B-R18 |
| Immunogen | recombinant Fas antigen |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | IHC-Fr, FC, IF |
| Working Dilutions | ,, |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | B-R18 specifically recognizes CD95. CD95 is a cell surface glycoprotein with a MW of 40-45 kDa and contains 8 kDa of N-glyosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. CD95 is preferentially expressed by the CD54RAlow and CD45ROhigh subset of memory T-cells, but it also found on peripheral monocytes. It is further found on human B-cell lines like pre-B cells, EBV infected cells, Burkitt cells and plasmacytoma cells. It also binds to human T-cell lines, myeloid cell lines, hepatocyte carcinoma and endothelial cells. |
| References | Sasaki et al. Br J Urol 81: 852, (1998). Sugihara et al. Anticancer Res 17: 3861, (1997). Kondo et al. J Pathol 183: 75, (1997) |
| Supplier | MONOSAN |
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