| Product Name | Mouse anti-CD98, clone IPO-T10 |
|---|---|
| Description | Mouse anti-CD98, clone IPO-T10 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | IPO-T10 |
| Immunogen | stimulated human PBL |
| Isotype | IgM |
| Reactivity | Human |
| Applications | IHC-Fr, FC |
| Working Dilutions | , |
| Diluent Buffer | PBS with 0.02% sodium azide |
| Concentration | 100 ug/ml |
| Storage | 2-8°C |
| Notes | CD98 exists as a heterodimer containing a disulphide-linked glycosylated heavy chain and a nonglycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through disulphide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intercellular calcium levels and transport L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. Monocytes express high levels of CD98 antigen. Peripheral blood T- and B-cells, as well as NKcells and granulocytes express low levels of CD98. Activation of T-cells and NK-cells leads to upregulation of CD98. RBCs are negative. IPO-T10 was typed at the VIth International Workshop and Conference on Human Leukocyte Differentiation Antigens |
| References | The VIth International Workshop and Conference on Human Leukocyte Differentiation Antigens, Kobe, Japan (1996). Woodhead VE et al. Int Immunol.12(7):1051-61 (2000). Stonehouse TJ et al. Immunology 96: 35–47 (1999) |
| Supplier | MONOSAN |
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