| Product Name | Mouse anti-Cytokeratin 8, clone 35betaH11 (Monoclonal) |
|---|---|
| Description | Mouse anti-Cytokeratin 8, clone 35betaH11 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 35betaH11 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgM |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | Cytokeratin 8, a member of the Type II family of cytokeratins, is typically expressed in simple epithelium. The dimerization of cytokeratin 8 with cytokeratin 18 (labeled by 35betaH11) in the cytoplasm of simple epithelial cells allows for the formation of an intermediate filament cytoskeletal framework. This structure plays a role in the maintenance of cellular structural integrity and also functions in promoting signal transduction and cellular differentiation processes. Additionally, the presence of cytokeratin 8 has been detected in neoplastic epithelia, including glandular epithelium that can be found in prostate carcinoma. Positive immunoreactivity with anti-cytokeratin 8 is a useful indicator for the identification of normal and neoplastic epithelial tissues. |
| References | Battifora, H. Am J Surg Pathol 1988;12:24. Gown, AM, et al. Am J Clin Pathol 1985;84:413. Ljung G, et al. Prostate. 1997; 31:91-7. Murata T, et al. Pathol Res Pract. 1993; 189:888-93. Moll R, et al. Histochem Cell Biol. 2008; 129:705-33 |
| Supplier | MONOSAN |
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