| Product Name | Mouse anti-Cytokeratin (HMW), clone 34betaE12 (Monoclonal) |
|---|---|
| Description | Mouse anti-Cytokeratin (HMW), clone 34betaE12 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 34betaE12 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1-k |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:500) |
| Diluent Buffer | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes |
The antibody is an antibody to high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1,5,10, and 14 that are found in complex epithelia. Anti-Cytokeratin, 34betaE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, and neural tumors are unreactive with this antibody with some exceptions. Anti-Cytokeratin, 34betaE12 does label myoepithelial cells and has been shown to be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations. |
| References | Gown AM, et al. Am J Pathol. 1984; 114:309. O’Malley FP, et al. Virch Arch A. 1990; 417:191-6. Wojno KJ, et al. Am J Surg Pathol. 1995; 19:251-60. Moinfar F, et al. Am J Surg Pathol. 1999; 23:1048-58. Yang XJ, et al. Am J Surg Pathol. 1999; 23:147-52 |
| Supplier | MONOSAN |
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