Mouse anti-Cytokeratin 5 (Liquid Primary Antibody), clone XM26 (monoclonal)
| Product Name | Mouse anti-Cytokeratin 5 (Liquid Primary Antibody), clone XM26 (monoclonal) |
|---|---|
| Description | Mouse anti-Cytokeratin 5 (Liquid Primary Antibody), clone XM26 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | XM26 |
| Immunogen | Prokaryotic recombinant fusion protein corresponding to a 103 amino acid portion of the C-terminal region of the human cytokeratin 5 molecule. |
| Isotype | IgG1, kappa |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100) |
| Diluent Buffer | Tissue culture supernatant with Sodium azide |
| Concentration | Greater than or equal to 21 mg/L |
| Storage | 2-8°C |
| Notes | Cytokeratins are a large family of cytoskeletal proteins found in epithelial cells. They are co-ordinately synthesized in pairs so that at least one member of each family is expressed in each epithelial cell. Cytokeratins assemble into obligatory heteropolymers composed of type I (acidic) and type II (basic) polypeptides to form higher order tetramers and protofilaments. Basal cells of human epidermis express acidic keratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kD protein that is closely related to cytokeratin 6. Point mutations in the cytokeratin 5 gene at locus 12q11-q13 can cause various types of epidermolysis bullosa simplex. Cytokeratin 5 is also reported to be expressed in most epithelial and biphasic mesotheliomas. Clone XM26 is specific for the 58 kD intermediate filament protein known as cytokeratin 5. It is not cross-reactive with cytokeratin 6. |
| References | Bhargava R et al. The American Journal of Clinical Pathology . 2008; 130:724-730. Laakso M e al. Clinical Cancer Research. 2006; 12(14):4185-4191. Miettinen M et al. American Journal of Surgical Pathology. 2003; 27(2):150–158. Zhang RR et al. Breast Cancer Research. 2003; 5:R151–R156 |
| Supplier | MONOSAN |
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