| Product Name | Mouse anti E-Cadherin, clone BS38 (Monoclonal) |
|---|---|
| Description | Mouse anti E-Cadherin, clone BS38 (Monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BS38 |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Reactivity | Canine, Human, Mouse, Porcine, Rabbit, Rat, Sheep |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:100-1:400) |
| Diluent Buffer | TRIS with 0.03% sodium azide, pH 7,2 |
| Concentration | n/a |
| Storage | 2-8°C |
| Notes | E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. |
| Supplier | MONOSAN |
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