Mouse anti-Epidermal Growth Factor Receptor, clone EGFR.113 (monoclonal)
| Product Name | Mouse anti-Epidermal Growth Factor Receptor, clone EGFR.113 (monoclonal) |
|---|---|
| Description | Mouse anti-Epidermal Growth Factor Receptor, clone EGFR.113 (monoclonal) |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | EGFR.113 |
| Immunogen | Prokaryotic fusion protein corresponding to the external domain of the epidermal growth factor receptor molecule. |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | IHC-P |
| Working Dilutions | IHC-P (1:20) |
| Diluent Buffer | Tissue culture supernatant with Sodium azide |
| Concentration | Greater than or equal to 26 mg/L |
| Storage | 2-8°C |
| Notes | Epidermal growth factor receptor (EGFR) is a transmembrane protein receptor of 170 kD with tyrosine kinase activity. Increased levels of EGFR are reported to be linked with malignant transformation of squamous cells eg in squamous cell carcinoma of the lung, head, neck, skin, cervix and esophagus. EGFR may also play a role in the development and progression of hepatocellular carcinomas where recurrence rates are higher in EGFR-positive cases. This correlation has similarly been reported in colorectal cancers where EGFR, produced by tumor cells, plays an important role in the invasiveness and proliferation of colorectal cancers. The majority of published studies of EGFR expression in human breast cancer has similarly shown an association with EGFR expression where it is inversely related to estrogen receptor status. |
| References | Lodge AJ et al. Journal of Clinical Pathology. 2003; 56(4):300–304. Sriplakich S et al. BJU Int. 1999; 83(4):498–503. Inoue K et al. Acta Med Okayama 1998; 52(6):305–310. Tungekar MF and Linehan J. Journal of Clinical Pathology. 1998; 51:583–587 |
| Supplier | MONOSAN |
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